MSM & Lupus
Excerpt from Dr Stanley W. Jacob’s book…
“The Miracle of MSM” The Natural Solution for Pain
It can be used in conjunction with cortisone, the standard medication, or alone. By itself it improves joint, skin, and vascular symptoms. Patients taking MSM for lupus disease symptoms experience results at least as good as from taking cortisone, but without the side effects associated with the drug.
MSM doesn’t cure systemic lupus erythematosus any more than cortisone does, but it is an effective treatment for lupus disease due in large part to its anti-inflammatory and immune-modulating actions.
Several dozen patients with lupus have been treated with overall good results. Almost three-quarters of them have benefited.
A promising role for MSM in auto-immune diseases was demonstrated by an animal study conducted at the Oregon Health Sciences University’s Department of Arthritis and Rheumatic Diseases in 1986. The experiment involved mice prone to autoimmune proliferative diseases resembling leukemia and lymphoma in humans.
Because of their susceptibility, the life span of these rodents is five and a half months. They develop anemia, lupuslike kidney disease, and enlargements of lymph nodes, spleen, and thymus.
In the study, one group of mice was provided either DMSO or MSM in their daily drinking water while the other group was maintained on normal water. After thirty-nine weeks, all of the nonsupplemented animals were dead. At forty-six weeks, nearly 80 percent of the supplemented mice were still living.
On average, DMSO and MSM nearly doubled the lifespan of the animals to ten months.
The supplemented mice remained healthy and vigorous throughout their lives, observed researchers Jane Morton and Benjamin Siegel. The animals showed significant reduction of anemia and the typical enlargements of lymph nodes and spleen.
Moreover, there were no signs of toxicity even on high doses of MSM – the equivalent of 6 to 8 grams per kilogram of body weight daily. By comparison, an adult human might take a total of 6 to 8 grams a day.
“We have found DMSO and DMSOZ (MSM) to be virtually identical in their ability to diminish the severity of these disorders,” Morton and Siegel reported in the journal Proceedings of the Society for Experimental Biology and Medicine. It is conceivable that DMSO2, which is the major metabolite of DMSO in the body, “may be the biologically effective molecule in these reactions,” they added.
The precise mechanism for this protective role is yet unclear. The researchers suggested that MSM might alter the role of antibodies and other immune system elements as well as the activity of certain immune-regulating molecules such as prostaglandins.
In a follow-up study with laboratory rodents using the same model, DMSO and MSM were again found to extend life span as well as reduce the severity of anemia and kidney damage and lessen the degree of spleen enlargement.
In this second study, some of the animals were started on DMSO and MSM when they were seven months old and their underlying terminal disease process was well underway. Even under these circumstances, their lives were extended substantially.
Morton and Siegel found a significant reduction in certain antibodies that react with DNA and cause kidney damage. “Although we are not sure about the mechanism of action, DMSO and MSM may act by decreasing inflammatory responses and the production of autoantibodies and immune complexes,” they concluded, recommending further studies.
Systemic lupus in humans is a destructive disease. It typically damages kidneys, and many people with the condition require kidney transplants. When MSM is taken as a supplement for lupus, patients demonstrate improved kidney function.
It is interesting to note that in the animal studies the researchers found that DMSO and MSM generated similar positive results for lupus symptoms. Since people generally won’t take DMSO for a long period of time because of the odor, the potential use of MSM as a long-term adjunct to treatment is well worth exploring for anyone with lupus